Department Molecular Genetics
Principal investigator Miao-Ping Chien
E-mail address m.p.chien@erasmusmc.nl
Website http://www.mpchienlab.org/
Microscopy-based functional single cell sequencing for cancer biology
In Dr. Chien’s lab, we develop single cell technologies combining optical imaging, biomedical and bioinformatics methods to address biological questions, particularly in cancer biology and immuno-oncology. There are two potential projects: one is to apply our microscopy-based functional single cell sequencing method to study the effect of fibroblasts on clonogenicity of cancer cells; another one is to help develop a spatial -omic profiling technology and apply it to investigate the interplay of cancer cells and tumor microenvironment.
Techniques
- Advanced imaging
- Image analysis
- Single cell sequencing
- Bioinformatics
Further reading
You, L., et al. (2022). Nature Biomedical Engineering, 6, 667–675 DOI: 10.1038/s41551-022-00853-x.