DNA repair research for tumor therapy optimization

Department                           Molecular Genetics

Principal investigator           Dik van Gent

E-mail address                       d.vangent@erasmusmc.nl


Optimizing predictive ex vivo assays for lung cancer

Supervisor: Zhongli Chen, z.chen@erasmusmc.nl

There are several different options for treatment of lung cancer with chemotherapy, targeted therapy and immunotherapy. However, there is currently no option to select the best treatment for each individual patient. Therefore, we are developing methods to grow small pieces of lung tumors in the lab and investigate how they react to various treatments. Projects encompass optimizing growth conditions and treatment schedules, as well as developing methods to allow automatic analysis of microscopic images before and after treatment.


  • Tissue culture
  • Immunofluorescence (confocal) microscopy
  • Automatic image analysis

Further reading

Zhang, W., et al. (2019). Prostate, 79(4), 390-402. DOI: 10.1002/pros.23745.