Cilia and signal transduction

Department                           Cell Biology

Principal investigator          Gert Jansen

E-mail address           


Molecular mechanism of neuronal cell fate maintenance

To maintain their proper functioning, cells must maintain their fate. However the molecular mechanisms that maintain cell fate are not well understood. We study this process in the ASE salt sensing neurons of C. elegans. We recently identified a transcription factor that contributes to ASE fate maintenance. In this project we will study the function of the transcription factor using molecular genetics, imaging techniques and behavioral assays.


  • elegans culture
  • Crosses
  • Microinjections
  • CRISPR/Cas9 genome editing
  • Auxin induced protein depletion
  • PCR
  • Fluorescence microscopy
  • Chemotaxis assays

Further reading

Traets, J.J.H., et al. (2021). eLife, 10, e66955. DOI: 10.7554/eLife.66955.