Department Neuroscience
Principal investigator Martijn Schonewille
E-mail address m.schonewille@erasmusmc.nl
Website www.neuro.nl/research/schonewille
Cerebellar development and differentiation in sensorimotor control
Supervisor: Martijn Schonewille, m.schonewille@erasmusmc.nl
In our lab we study the development and contribution of different cell types to sensorimotor integration in the cerebellum, across a wide variety of technical approaches. Approaches range from in utero electroporation followed by morphological analysis, molecular biological techniques, electrophysiological recording in and ex vivo across life to various behavioral tasks. The goal is to 1) determine the key intrinsic processes, genetic and activity-dependent, that are require for proper cerebellar development and affected in neurodevelopmental disorders and 2) understand what features are contributed by different subpopulations of neurons to movement control and how these are affected in ataxia and other neurodegenerative disorders.
Techniques
- molecular biological approaches (western blot, immunohistochemistry, RNAseq, qPCR)
- ex vivo electrophysiology
- home cage motion monitoring
- in vivo electrophysiological recordings
- various behavioral tasks.
Further reading
Purkinje cell microzones mediate distinct kinematics of a single movement
Pre-ataxic loss of intrinsic plasticity and motor learning in a mouse model of SCA1