Radiobiology of radionuclide therapy

Department                             Molecular Genetics

Principal investigator          Julie Nonnekens

E-mail address                        j.nonnekens@erasmusmc.nl

Website                                     www.nonnekenslab.com

 

Radiation biology of radioactive anticancer treatment

Suitable as a BEP? Yes

Suitable as a MEP? Yes

Suitable as an Academic Research Project? Yes

Techniques:

  • Cell culture
  • (Live cell) microscopy
  • Molecular techniques
  • Monte Carlo simulations
  • Deep learning based image analysis
  • Bioinformatics

Various preclinical projects available all focusing on gaining a clear view of how cancer cells respond to radioactive anticancer treatment with the goal better understand the dose-effect relationship. We goal in the long run is to predict upfront whether a patient can be successfully treated or not.

Further reading

PMID: 40404397, 39061156, 37351169, 36765883, 35556158

 

(Example) projects submitted by lab in past years

(2024-2025) Live cell imaging of DNA damage processes induced by radiation

Supervisor: Julie Nonnekens, j.nonnekens@erasmusmc.nl

Techniques

  • Live cell confocal microscopy
  • Cell culture
  • Immunofluorescent stainings

 

(2024-2025) Molecular biology of radiation induced cellular processes

Supervisor: Julie Nonnekens, j.nonnekens@erasmusmc.nl

Techniques

  • Cell culture
  • Western blotting
  • Flow cytometry
  • qPCR
  • Immunofluorescence

 

(2024-2025) Deep learning based confocal image analysis

Supervisor: Julie Nonnekens, j.nonnekens@erasmusmc.nl

Techniques

  • Programming (python or image J)

 

(2024-2025) Monte Carlo simulations for dosimetry of radionuclide therapy

Supervisor: Julie Nonnekens, j.nonnekens@erasmusmc.nl

Techniques

  • Programming (C)