Department Molecular Genetics
Principal investigator Jurgen Marteijn
E-mail address j.marteijn@erasmusmc.nl
Website https://www.genomestability.nl/
Effects of DNA damage on transcription
Our lab studies the effects of DNA damage on transcription, how this transcription-blocking DNA damage is repaired and how this contributes to aging and age-related diseases. We have different interesting projects using live cell imaging , gene editing and proteomics techniques to identify new factors involved in this process and to better understand the repair mechanisms.
Techniques
- CRISPR/Cas9
- Live cell imaging
- Image analysis
- Cell culture
- Proteomics
- Single molecule imaging
- DNA damage induction
Further reading
Steurer, B., et al. (2022). Nature Communications, 13(3624). DOI: 10.1038/s41467-022-31329-w.
Van Toorn, M., et al. (2022). Molecular Cell, 82, 1343–1358. DOI: 10.1016/j.molcel.2022.02.020.