Marteijn Group

Department                          Molecular Genetics

Principal investigator          Jurgen Marteijn

E-mail address            



Effects of DNA damage on transcription

Our lab studies the effects of DNA damage on transcription, how this transcription-blocking DNA damage is repaired and how this contributes to aging and age-related diseases. We have different interesting projects using live cell imaging , gene editing and proteomics techniques to identify new factors involved in this process and to better understand the repair mechanisms.


  • CRISPR/Cas9
  • Live cell imaging
  • Image analysis
  • Cell culture
  • Proteomics
  • Single molecule imaging
  • DNA damage induction

Further reading

Steurer, B., et al. (2022). Nature Communications, 13(3624). DOI: 10.1038/s41467-022-31329-w.

Van Toorn, M., et al. (2022). Molecular Cell, 82, 1343–1358. DOI: 10.1016/j.molcel.2022.02.020.