Department Bionanoscience
Principal investigator Liedewij Laan
E-mail address L.laan@tudelft.nl
Website www.tudelft.nl/laanlab
Minimal polarizing synthetic cells
Suitable as a BEP? Yes
Suitable as a MEP? Yes
Suitable as an Academic Research Project? No
Techniques:
- Microflluidics
- Fluorecence microscopy
The aim of this project is to investigate how function and robustness emerges from the collective physical properties in a complex, self-organizing, synthetic polarity network encapsulated in a membrane vesicle.
Further reading (click to link to article)
Tschirpke et al, biorxiv 2024
Robustness of core cellular processes
Suitable as a BEP? Yes
Suitable as a MEP? Yes
Suitable as an Academic Research Project? No
Techniques:
- Live cell microscopy
- Genetics and/or physical modeling
How is it possible that core cellular functions are conserved, while the responsible molecular networks dramatically diversify? You will work on aspects of this question using polarity establishment in Saccharomyces as a model system.