Department Netherlands Cancer Institute
Principal investigator Benjamin Rowland
E-mail address b.rowland@nki.nl
Website https://www.nki.nl/research/research-groups/benjamin-rowland/
Shaping the genome with SMC motors
Suitable as a BEP? Yes
Suitable as a MEP? Yes
Suitable as an Academic Research Project? Yes
Techniques:
- Genetics
- Genomics
- Biochemistry
- Structural biology
- Imaging.
How do cohesin and condensin build DNA loops and shape the genome in 3D? How do these complexes entrap and release DNA? How does cohesin stably lock together the sister chromatids? How does condensin drive mitotic chromosome condensation? How does the SMC5/6 complex silence viral genomes? And how does the action of these complexes affect nuclear organization, gene expression, and genomic stability?
These are the kind of questions that keep us awake at night and drive our research. We are addressing such questions using a multi-disciplinary approach that involves genetics, genomics, biochemistry and imaging.
Further reading (click to link to article)
https://www.nature.com/articles/s41580-023-00609-8