Department Neuroscience
Principal investigator Aleksandra Badura
E-mail address a.badura@erasmusmc.nl
Website www.neuro.nl/research/badura
Variability of neuronal activity and morphology in mouse model of Autism Spectrum Disorder
Supervisor: Ines Serra, i.dasilvaserra@erasmusmc.nl
We put a hand in, and nine out of ten times we locate what we were looking for. But sometimes we do not — that is when we take advantage of behavioral flexibility, an ability to adapt strategies to face new and unexpected conditions. However, in some disorders this adaptation does not occur or is impaired. But how is this richness of flexible behavior or the lack thereof determined by the brain?
Our group aims to understand how cerebello-cortical brain activity translates into behaviors that adapt to ever-changing environments. We are particularly interested in uncovering the mechanisms of maladaptive perseverative behaviors characteristic of autism spectrum disorder.
Techniques
- Electrophysiology
- Animal pose tracking estimation
- GLM
- Dimensionality reduction computational methods
- Immunocytochemistry
- Confocal microscopy