Job Offers

PhD student DRIVE-RM – 38 hours p/w

Utrecht Science Park, Netherlands
Posted: 12-06-2025
Application deadline: Applications are considered on a rolling basis until the position is filled. Apply as soon as possible.

Cardiovascular disease is the leading cause of death worldwide, largely due to the human heart’s limited capacity to regenerate after injury. In contrast, zebrafish have a remarkable ability to fully regenerate their heart, making them a powerful model for uncovering the biological principles underlying tissue regeneration.
In this project, we aim to identify key molecular pathways that drive successful heart regeneration. Our recent work uncovered an epigenetic mechanism involving the chromatin architectural factor HMGA1, which promotes heart regeneration in zebrafish and enhances regeneration in a mouse model of cardiac injury (Bouwman et al., Nature Cardiovascular Research, 2025).
We will apply single-cell transcriptomics (scRNA-seq) and epigenomics (ATAC-seq and T-ChIC) to further understand how this epigenetic pathway governs cellular dedifferentiation and plasticity during regeneration in the heart and other tissues.
You will lead the analysis, integration, and interpretation of single-cell omics datasets, and optimize bioinformatic pipelines. You will work closely with wet-lab team members to co-develop, analyze, and interpret the data. This research is embedded in DRIVE-RM, a large national research consortium focused on regenerative medicine. The insights from this work will contribute to our understanding of tissue regeneration and support the development of novel regenerative therapies for human heart disease.

For more information about the position visit https://www.hubrecht.eu/job/phd-student-drive-rm-38-hours-p-w/
For more information about the Consortium visit https://drive-rm.nl/
For questions please contact j.bakkers@hubrecht.eu

PhD position
Heidelberg University, Germany
Posted: 10-03-2025
Application deadline: Applications are considered on a rolling basis until the position is filled. Apply as soon as possible.

Interested in RNA origami, synthetic cells, membranes, directed evolution and/or cryoEM? Looking for a PhD position in friendly group in Germany and an excellent European network? The Biophysical Engineering Group at Heidelberg University is looking for a new member. We have an open PhD position within the Marie Curie training network SigSynCell. Together with nine other groups around Europe, we would like to make synthetic cells sense and respond to their environment. In our group, our strategy is to build up transmembrane signalling units with RNA origami. Those will be expressed in synthetic cells and displayed on their surface. We will use directed evolution to optimize the RNA origami and thus our synthetic cells.

To find out more about us: https://goepfrichgroup.de
To find out more about SigSynCell: https://sigsyncell.crpp.cnrs.fr/
Any questions about the group? Email William, a Nanobiology alumnus who is currently doing his PhD with us (w.verstraeten@zmbh.uni-heidelberg.de):
Interested? Please contact Kerstin with a CV and a transcript of records (k.goepfrich@zmbh.uni-heidelberg.de).

Working student vacancy
NextHuman AI Consulting
Posted: 30-04-2024
Application deadline: –

Are you looking for a challenging work experience? At NextHuman we have an opportunity for you! As a working student, you will join a dynamic eam helping organisations with important social functions to manifest and scale up AI, whilst determining the course of how AI will be used in our society. At NextHuman you contribute to building our fast-growing company and support our team in various operational tasks and projects, where you will have the opportunity to gain practical experience in the field of AI. View the vacancy here: https://lnkd.in/eswihyHi