Department Radiology & Nuclear Medicine
Principal investigator Esther Warnert
E-mail address e.warnert@erasmusmc.nl
Website https://drive.google.com/file/d/1YOJPzNqKprsiow5OvOPdvAzYnohoPwYV/view?usp=sharing
Validation of Amide Proton Transfer Chemical Exchange Saturation Transfer MRI in brain tumours
Suitable as a BEP? No
Suitable as a MEP? Yes
Suitable as an Academic Research Project? Yes
Techniques:
- MRI
- Proteomics
- Statistics
APT CEST MRI is a novel imaging technique that holds the promise to image protein content in human brain tumors. To validate the use of this technique in clinical practice, we performed this technique in patients with brain tumors prior to surgery. We obtained 65 targeted biopsies of the tumors, which were planned on the APT CEST MRI images. These biopsies were analysed with proteomics, and > 3000 proteins were identified. We are looking for a student who is keen on linking these results from advanced MRI and proteomics together to inform on tumour biology.
Further reading (click to link to article)
https://link.springer.com/article/10.1007/s10334-021-00996-z
Quantitative BOLD MRI for personalized radiotherapy treatment in patients with glioblastoma
Suitable as a BEP? Yes
Suitable as a MEP? Yes
Suitable as an Academic Research Project? Yes
Techniques:
- Perfusion and BOLD MRI
- MR physics
- Acquisition
- Post-processing
- Radiotherapy
In the MOSAIC trial we are integrating advanced MRI biomarkers of physiology into the radiotherapy treatment planning of patients diagnosed with glioblastoma (high grade brain tumour). The MRI techniques included here measure perfusion (Arterial Spin Labelling, Dynamic Susceptibility Contrast) and oxygen content (quantitative Blood-Oxygen Level Dependent imaging). We are looking for enthusiastic students that would like to work on developing a measurement of cerebral oxygen metabolism in brain tumor patients and work on integrating this measurement in clinical practice.
Further reading (click to link to article)
https://link.springer.com/article/10.1007/s10334-021-00997-y
Validation of liver oxgen MRI in patients with Hepatocellular Carcinoma
Suitable as a BEP? No
Suitable as a MEP? Yes
Suitable as an Academic Research Project? Yes
Techniques:
- MRI (acquisition, physiological modelling, image processing),
- Histology staining for vasculature
- Hypoxia
We have made first developments of an MRI technique that can measure liver oxygen content. We are now planning a small pilot study in which we intend to include 10 patients with hepatocellular carcinoma in which this technique will be validated with measurements of histology. Patients will undergo an MRI scan prior to surgery/ablation. During this procedures, additional biopsies will be taken based on our novel measurement of liver oxygen content. Validation will occur through matching our MRI-based measurement of oxygen content to pathology-based measurements of hypoxia.
Further reading (click to link to article)
https://repository.tudelft.nl/record/uuid:a8ffe69f-c667-46df-8b16-0935221bc7f0