Department Internal Medicine
Principal investigator Eskeatnaf Mulugeta
E-mail address e.mulugeta@erasmusmc.nl
Website https://www.erasmusmc.nl/en/research/researchers/mulugeta-eskeatnaf
The role of the non coding genome in endocrine tumors
Suitable as a BEP? Yes
Suitable as a MEP? Yes
Suitable as an Academic Research Project? No
Techniques:
- Dry-lab (computational biology)
- AI
- Programming
Approximately 97% of the human genome is non-coding, and its essential regulatory functions have become increasingly apparent in recent years. Elements within these non-coding regions control gene expression and cellular function, and their disruption can contribute to disease development, including cancer. This project aims to identify and characterize non-coding genomic regions that play key regulatory roles in endocrine tumors by integrating computational and experimental approaches. Using existing genomic and epigenomic datasets, we will pinpoint candidate regulatory elements and assess their functional relevance through targeted laboratory validation. By combining dry-lab (computational biology) and wet-lab (experimental) methods, this project seeks to uncover novel insights into the non-coding genome’s contribution to endocrine tumor biology.
Further reading (click to link to article)
https://doi.org/10.1186/s13073-021-00980-1